This information applies to version(s): 3, 4, 5
The non-destructive workflow is available with Adobe Lightroom Classic CC and DxO PhotoLab 2 (and subsequent versions of DxO PhotoLab). However, it is not possible to combine multiple plug-ins while using a non-destructive workflow. The non-destructive workflow is limited to only 1 plugin non-destructiveness / 1 plugin unlimited back and forth.
To view the user guide directly from this article, please click on this link.